Search Results
| Date | Team | Acquired | Relinquished | Notes |
| 2021-10-08 | Titans | • Tommy Hudson | placed on IR with ankle injury | |
| 2021-10-12 | Jaguars | • Brandon Linder | placed on IR with sprained MCL in knee, ankle injury | |
| 2021-10-12 | Rams | • Darious Williams | placed on IR with ankle injury | |
| 2021-10-15 | Giants | • Justin Hilliard | placed on IR with ankle injury | |
| 2021-10-19 | Browns | • Jeremiah Owusu-Koramoah | placed on IR with ankle injury | |
| 2021-10-19 | Giants | • Andrew Thomas | placed on IR with left ankle / foot injury | |
| 2021-10-19 | Ravens | • Ronnie Stanley | placed on IR with ankle injury | |
| 2021-10-26 | Panthers | • John Miller (b. 1993-08-12) | placed on IR with ankle injury | |
| 2021-10-30 | Eagles | • Miles Sanders | placed on IR with ankle, foot injuries | |
| 2021-11-01 | Giants | • Carter Coughlin | placed on IR with ankle injury | |
| 2021-11-09 | Broncos | • Graham Glasgow | placed on IR with fractured left ankle | |
| 2021-11-10 | Dolphins | • Greg Mancz | placed on IR with ankle injury | |
| 2021-11-10 | Raiders | • Darius Philon | placed on IR with ankle injury | |
| 2021-11-13 | Cardinals | • Chase Edmonds | placed on IR with high ankle sprain | |
| 2021-11-13 | Patriots | • Jamie Collins | placed on IR with ankle injury | |
| 2021-11-17 | Patriots | • Josh Uche | placed on IR with ankle injury | |
| 2021-11-18 | Falcons | • Hayden Hurst | placed on IR with ankle injury | |
| 2021-11-20 | Steelers | • Kevin Dotson | placed on IR with ankle injury | |
| 2021-11-24 | Lions | • A.J. Parker | placed on IR with ankle injury | |
| 2021-11-25 | Giants | • Nate Ebner | placed on IR with ankle / knee injury | |
| 2021-11-27 | Jets | • Michael Carter (b. 1999-05-07) | placed on IR with high ankle sprain | |
| 2021-11-30 | Eagles | • Jack Driscoll | placed on IR with high ankle sprain | |
| 2021-11-30 | Panthers | • Christian McCaffrey | placed on IR with ankle injury | |
| 2021-11-30 | Titans | • Monty Rice | placed on IR with ankle injury | |
| 2021-12-02 | Broncos | • Calvin Anderson | placed on IR with ankle, knee injuries |
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